氧化石墨烯修饰肽纳米技术 对人体多能干细胞的增值抑制作用研究
摘要
氧化石墨烯（Graphene oxide，GO）作为一种石墨烯的衍生物，能够影响细胞行为和分化，在干细胞治 疗方面发挥着非常重要的作用。为了实现诱导人多能干细胞（ihPSCs）在干细胞治疗中的治疗前景，本研究开发 出简单安全的ihPSCs增殖和成骨细胞谱系生物材料。构建了含氧化石墨烯（GO）的聚己内酯（PCL）修饰成骨肽 （BFP-1）微环境电纺纳米纤维支架，以改善ihPSC的体外细胞生长和成骨能力。使用CCK-8测定法评估ihPSCs的 粘附和增殖，结果表明ihPSCs能够有效增殖并保持无基质凝胶的成骨肽涂层纳米纤维的多能性。该研究结果在加速 ihPSCs在骨组织工程中的再生潜力方面具有相当大的应用前景。参考
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