皮肤免疫衰老与自身免疫病所导致的皮肤病变相关性回顾
摘要
免疫衰老涉及中枢及外周免疫器官,可在皮肤中引起多种免疫细胞及细胞因子的数量和功能改 变,并在天疱疮、系统性红斑狼疮、系统性硬化、斑秃等疾病的发病中发挥重要作用。本文对皮肤免疫衰老和 皮肤疾病的关系进行综述,为相关疾病的病因学研究与临床诊疗提供参考。参考
[1]Shi Junhe., Barakat May., Chen Dandan., Chen
Lin.(2018). Bicellular Tight Junctions and Wound Healing.
Int J Mol Sci, 19(12). doi:10.3390/ijms19123862
[2]Niyonsaba François., Kiatsurayanon Chanisa.,
Chieosilapatham Panjit., Ogawa Hideoki.(2017). Friends
or Foes? Host defense (antimicrobial) peptides and proteins
in human skin diseases. Exp Dermatol, 26(11), 989-998.
doi:10.1111/exd.13314
[3]Nguyen Alan V., Soulika Athena M.(2019). The
Dynamics of the Skin’s Immune System. Int J Mol Sci,
20(8), undefined. doi:10.3390/ijms20081811
[4]Collins Nicholas., Jiang Xiaodong., Zaid Ali.,
Macleod Bethany L., Li Jane., Park Chang Ook., Haque
Ashraful., Bedoui Sammy., Heath William R., Mueller
Scott N., Kupper Thomas S., Gebhardt Thomas., Carbone
Francis R.(2016). Skin CD4(+) memory T cells exhibit
combined cluster-mediated retention and equilibration
with the circulation. Nat Commun, 7(undefined), 11514.
doi:10.1038/ncomms11514
[5]Seidel J A., Vukmanovic-Stejic M., MullerDurovic B., Patel N., Fuentes-Duculan J., Henson S M.,
Krueger J G., Rustin M H A., Nestle F O., Lacy K E.,
Akbar A N.(2018). Skin resident memory CD8 T cells are
phenotypically and functionally distinct from circulating
populations and lack immediate cytotoxic function. Clin
Exp Immunol, 194(1), 79-92. doi:10.1111/cei.13189
[6]Ujiie Hideyuki.(2019). Regulatory T cells in
autoimmune skin diseases. Exp Dermatol, 28(6), 642-646.
doi:10.1111/exd.13535
[7]Boniface Katia., Jacquemin Clément., Darrigade
Anne-Sophie., Dessarthe Benoît., Martins Christina.,
Boukhedouni Nesrine., Vernisse Charlotte., Grasseau Alexis.,
Thiolat Denis., Rambert Jérôme., Lucchese Fabienne.,
Bertolotti Antoine., Ezzedine Khaled., Taieb Alain., Seneschal
Julien.(2018). Vitiligo Skin Is Imprinted with Resident
Memory CD8 T Cells Expressing CXCR3. J Invest Dermatol,
138(2), 355-364. doi:10.1016/j.jid.2017.08.038
[8]Nakashima C., Ishida Y., Nakagawa K., Irie H.,
Hirata M., Kataoka T., Otsuka A., Kabashima K.(2020).
Identification of CD49a+ CD8+ resident memory T cells
in vitiligo-like lesions associated with nivolumab treatment
for melanoma. J Eur Acad Dermatol Venereol, 34(2),
e79-e82. doi:10.1111/jdv.15970
[9]Kurihara Kazuo., Fujiyama Toshiharu.,
Phadungsaksawasdi Pawit., Ito Taisuke., Tokura Yoshiki.
(2019). Significance of IL-17A-producing CD8CD103
skin resident memory T cells in psoriasis lesion and their
possible relationship to clinical course. J Dermatol Sci,
95(1), 21-27. doi:10.1016/j.jdermsci.2019.06.002
[10]Del Duca E., Ruano Ruiz J., Pavel A B., Sanyal
R D., Song T., Gay-Mimbrera J., Zhang N., Estrada Y D.,
Peng X., Renert-Yuval Y., Phelps R G., Paus R., Krueger
J G., Guttman-Yassky E.(2020). Frontal fibrosing alopecia
shows robust T helper 1 and Janus kinase 3 skewing. Br J
Dermatol, 183(6), 1083-1093. doi:10.1111/bjd.19040
[11]Sheu T-T, Chiang B-L, Yen J-H, Lin W-C
(2014) Premature CD4+ T Cell Aging and Its Contribution
to Lymphopenia-Induced Proliferation of Memory Cells
in Autoimmune-Prone Non-Obese Diabetic Mice. PLoS
ONE 9(2): e89379. doi:10.1371/journal.pone.0089379
[12]Sibaii Hiba., El-Zayat Salwa Refat., Khalil
Mona.(2020). When wrinkles appear on the immune
system can it be reversed? Eur Cytokine Netw, 31(1), 1-17.
doi:10.1684/ecn.2020.0441
[13]Valdes-Rodriguez Rodrigo., Stull Carolyn.,
Yosipovitch Gil.(2015). Chronic pruritus in the elderly:
pathophysiology, diagnosis and management. Drugs Aging,
32(3), 201-15. doi:10.1007/s40266-015-0246-0
[14]Tanei Ryoji., Hasegawa Yasuko.(2016). Atopic
dermatitis in older adults: A viewpoint from geriatric
dermatology. Geriatr Gerontol Int, null(undefined), 75-86.
doi:10.1111/ggi.12771
[15]Batista Mariana D., Tincati Camilla., Milush
Jeffrey M., Ho Emily L., Ndhlovu Lishomwa C., York
Vanessa A., Kallas Esper G., Kalil Jorge., Keating Sheila M.,
Norris Philip J., Chang David., Unemori Patrick., Leslie
Kieron S., Maurer Toby., Liao Wilson., Nixon Douglas
F.(2013). CD57 expression and cytokine production by
T cells in lesional and unaffected skin from patients with
psoriasis. PLoS One, 8(2), e52144. doi:10.1371/journal.
pone.0052144