静脉注射 Lidocaine 对小鼠心脑血管的影响
摘要
利多卡因(Lidocaine)是局部麻醉及抗心律失常药作为一类古老的治疗心率失常药物,它有效 防治急性心肌梗死及各种心脏病并发快速室性心律失常。但是利多卡因药物对心脑血管具有一定的副作用,本 次设计实验探究病理小鼠模型在利多卡因治疗的生理生化变化,具有一定临床指导意义。参考
[1]National Center for Biotechnology Information
(2022). PubChem Compound Summary for CID 3676,
Lidocaine. Retrieved December 10, 2022 from https://
pubchem.ncbi.nlm.nih.gov/compound/Lidocaine.
[2] 宋宪蓉 . 对乙酰氨基酚引起高铁血红蛋白血症
三例 [J]. 中国药物与临床 ,2015,15(02):294-295.
[3]Kasanuki H, Ohnishi S, Tanaka E, Hirosawa K.
Clinical significance of Vanghan Williams classification for
treatment of ventricular tachycardia: study of class IA and
IB antiarrhythmic agents. Jpn Circ J. 1988 Mar;52(3):280-
8. doi: 10.1253/jcj.52.280. PMID: 3373720.
[4]Reiter MJ, Easley AR, Mann DE. Efficacy of class
Ib (lidocaine-like) antiarrhythmic agents for prevention
of sustained ventricular tachycardia secondary to coronary
artery disease. Am J Cardiol. 1987 Jun 1;59(15):1319-24.
doi: 10.1016/0002-9149(87)90912-x. PMID: 3109228.
[5] 孙安会 , 谷捷 , 吴涛 , 袁肇凯 , 蔡雄 , 胡志希 ,
简伟雄 , 李鑫 . 四种常用实验麻醉药物对大鼠心血管系
统的影响 [J]. 中国实验动物学报 ,2016,24(02):120-126.
[6] 王金保 , 王媛 , 程建征 . 复方利多卡因乳膏涂
覆气管导管干预呼吸机相关肺炎的动物实验研究 [J].
临床误诊误治 ,2012,25(01):56-58.
[7]Yang Y, Ou M, Liu J, Zhao W, Zhuoma L, Liang
Y, Zhu T, Mulkey DK, Zhou C. Volatile Anesthetics
Activate a Leak Sodium Conductance in Retrotrapezoid
Nucleus Neurons to Maintain Breathing during Anesthesia
in Mice. Anesthesiology. 2020 Oct 1;133(4):824-838.
doi: 10.1097/ALN.0000000000003493. Erratum in:
Anesthesiology. 2021 Jan 1;134(1):138. PMID: 32773689;
PMCID: PMC7494541.