利用 STITCH 分析 MDM2 网络交互作用
摘要
MDM2 是在多种肿瘤中扩增和高表达的原癌蛋白，不仅在肿瘤发生中，在胚胎发育过程中也 能对 p53 发挥特异性的抑制作用，不可逆地降低 p53 活性，使 p53 失去对肿瘤的抑制作用。STITCH（Search Tool For Interactions Of Chemicals），通过集成代谢网络，蛋白分子晶体结构，信号转导等信息，建立实验和药 物靶标之间的联系。由表型效应、文本采集和化学结构相似性推断得到的信息不仅能够用来研究已知的蛋白功 能，同时还能够预测未知蛋白之间的相互作用。参考
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