利用 STITCH 分析 MDM2 网络交互作用
摘要
MDM2 是在多种肿瘤中扩增和高表达的原癌蛋白,不仅在肿瘤发生中,在胚胎发育过程中也 能对 p53 发挥特异性的抑制作用,不可逆地降低 p53 活性,使 p53 失去对肿瘤的抑制作用。STITCH(Search Tool For Interactions Of Chemicals),通过集成代谢网络,蛋白分子晶体结构,信号转导等信息,建立实验和药 物靶标之间的联系。由表型效应、文本采集和化学结构相似性推断得到的信息不仅能够用来研究已知的蛋白功 能,同时还能够预测未知蛋白之间的相互作用。参考
[1]Cahilly-Snyder L, Yang-Feng T, Francke U, et al.
Molecular analysis and chromosomal mapping of amplified
genes isolated from a transformed mouse 3T3 cell line[J].
Somatic cell and molecular genetics, 1987, 13(3): 235-244.
[2]Xiao G, White D, Bargonetti J. p53 binds to a
constitutively nucleosome free region of the mdm2 gene[J].
Oncogene, 1998, 16(9): 1171-1181.
[3]Oliner J D, Kinzler K W, Meltzer P S, et al.
Amplification of a gene encoding a p53-associated protein
in human sarcomas[J]. 1992.
[4]Trotta R, Vignudelli T, Candini O, et al. BCR/
ABL activates mdm2 mRNA translation via the La
antigen[J]. Cancer cell, 2003, 3(2): 145-160.
[5]Haupt Y, Maya R, Kazaz A, et al. Mdm2 promotes
the rapid degradation of p53[J]. Nature, 1997, 387(6630):
296-299.
[6]FreedmanDA,WuL,LevineAJ.Functions of the
MDM2 oncoprotein [J].CeII MoI Life Sci,1999,55(1):
96-107.
[7]Piette J, NeeI H, MarechaI V. MDM2:keeping
p53 under control [J]. Oncogene, 1997, 15(9):1001-
1010.
[8]C.E. Wheelock, A. M. Wheelock, S. Kawashima,
D. Diez, M. Kanehisa, M. van Erk, R. Kleemann, J. Z.
Haeggstrom and S. Goto, Mol Biosyst, 2009, 5, 588-602.
[9]J. M. Harrold, M. Ramanathan and D. E. Mager,
Clin Pharmacol Ther, 2013, 94, 651-658.
[10]M. Kuhn, D. Szklarczyk, A. Franceschini, C. von
Mering, L. J. Jensen and P. Bork, Nucleic Acids Res, 2012,
40, D876-880.
[11]M. Kuhn, D. Szklarczyk, S. Pletscher-Frankild,
T. H. Blicher, C. von Mering, L. J. Jensen and P. Bork,
Nucleic Acids Res, 2014, 42, D401-407.
[12]M. Kuhn, C. von Mering, M. Campillos, L. J.
Jensen and P. Bork, Nucleic Acids Res, 2008, 36, D684-
688.
[13]M. Kuhn, D. Szklarczyk, A. Franceschini, M.
Campillos, C. von Mering, L. J. Jensen, A. Beyer and P.
Bork, Nucleic Acids Res, 2010, 38, D552-556.
[14]L. Chen, B. Q. Li, M. Y. Zheng, J. Zhang, K. Y.
Feng and Y. D. Cai, Biomed Res Int, 2013, 2013, 723-
780.
[15]N. T. Doncheva, Y. Assenov, F. S. Domingues
and M. Albrecht, Nat Protoc, 2012, 7, 670-685.
[16]Y. Assenov, F. Ramirez, S. E. Schelhorn, T.
Lengauer and M. Albrecht, Bioinformatics, 2008, 24, 282-
284.
[17]R. Saito, M. E. Smoot, K. Ono, J. Ruscheinski, P.
L. Wang, S. Lotia, A. R. Pico, G. D. Bader and T. Ideker,
Nat Methods, 2012, 9, 1069-1076. [24] W. Zhu, L. Yang
and Z. Du, PLoS One, 2009, 4, e6288.
[18]B. Q. Li, B. Niu, L. Chen, Z. J. Wei, T. Huang,
M. Jiang, J. Lu, M. Y. Zheng, X. Y. Kong and Y. D. Cai,
PLoS One, 2013, 8, e65207.
[19]L. Bonetta, Nature, 2010, 468, 851-854.
[20]T. I deker and N. J. Krogan, Mol Syst Biol, 2012,
8, 565.