室性早搏患病分布、病因和预后的研究现状

李 文钰

李文钰北京大学第三医院北方院区，中国·北京 102488

关键词: 室性早博；病因；发病年龄；预后

摘要

普通人群中室性早搏（室早）的预后存在一定的争议。过去认为室早大部分是良性的，近年来一些新的研究再次对室早与心脏功能以及远期预后间的关系进行了分析，有了一些新的进展。本文诣在总结优秀研究成果，对上述问题作出新的分析。同时启发我们进一步开展临床研究，以求能对家开展临床工作有一定帮助。

参考

Bikkina, M., M.G. Larson, and D. Levy, Prognostic implications of asymptomatic ventricular arrhythmias: the Framingham Heart Study. Ann Intern Med,

117(12): p. 990-6.

Manolio, T.A., et al., Cardiac arrhythmias on 24-h ambulatory electrocardiography in older women and men: the Cardiovascular Health Study. J Am Coll

Cardiol, 1994. 23(4): p. 916-25.

Hirose, H., et al., Cardiac mortality of premature ventricular complexes in

healthy people in Japan. J Cardiol, 2010. 56(1): p. 23-6.

Yang, J., et al., Characteristics of unselected high-burden premature ventricular contraction patients. Pacing Clin Electrophysiol, 2014. 37(12): p. 1671-80.

Wang, Y., et al., Cellular mechanism of premature ventricular contraction-induced cardiomyopathy. Heart Rhythm, 2014. 11(11): p. 2064-72.

Kennedy, H.L., et al., Long-term follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med, 1985. 312(4): p.

-7.

Epstein, A.E., et al., Mortality following ventricular arrhythmia suppression

by encainide, flecainide, and moricizine after myocardial infarction. The original

design concept of the Cardiac Arrhythmia Suppression Trial (CAST). JAMA, 1993.

(20): p. 2451-5.

Mason, J.W., A comparison of electrophysiologic testing with Holter monitoring to predict antiarrhythmic-drug efficacy for ventricular tachyarrhythmias.

Electrophysiologic Study versus Electrocardiographic Monitoring Investigators. N

Engl J Med, 1993. 329(7): p. 445-51.

Abdalla, I.S., et al., Relation between ventricular premature complexes and

sudden cardiac death in apparently healthy men. Am J Cardiol, 1987. 60(13): p.

-42.

.Hedblad, B., et al., Survival and incidence of myocardial infarction in

men with ambulatory ECG-detected frequent and complex ventricular arrhythmias.

year follow-up of the 'Men born 1914' study in Malmo, Sweden. Eur Heart J,

18(11): p. 1787-95.

.Ataklte, F., et al., Meta-analysis of ventricular premature complexes and

their relation to cardiac mortality in general populations. Am J Cardiol, 2013. 112

(8): p. 1263-70.

.Dukes, J.W., et al., Ventricular Ectopy as a Predictor of Heart Failure and

Death. J Am Coll Cardiol, 2015. 66(2): p. 101-9.

.Bogun, F., et al., Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention.

Heart Rhythm, 2007. 4(7): p. 863-7.

.Aronow, W.S., et al., Effect of quinidine or procainamide versus no antiarrhythmic drug on sudden cardiac death, total cardiac death, and total death in

elderly patients with heart disease and complex ventricular arrhythmias. Am J Cardiol,

66(4): p. 423-8.

.Hallstrom, A.P., et al., An antiarrhythmic drug experience in 941 patients

resuscitated from an initial cardiac arrest between 1970 and 1985. Am J Cardiol,

68(10): p. 1025-31.

.Morganroth, J. and J.E. Goin, Quinidine-related mortality in the shortto-medium-term treatment of ventricular arrhythmias. A meta-analysis. Circulation,

84(5): p. 1977-83.

.Torp-Pedersen, C., et al., Dofetilide in patients with congestive heart

failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and

Mortality on Dofetilide Study Group. N Engl J Med, 1999. 341(12): p. 857-65.

.Waldo, A.L., et al., Effect of d-sotalol on mortality in patients with left

ventricular dysfunction after recent and remote myocardial infarction. The SWORD

Investigators. Survival With Oral d-Sotalol. Lancet, 1996. 348(9019): p. 7-12.