细胞周期蛋白依赖性激酶抑制剂在结直肠癌治疗中的前景

  • 曹 阳 内蒙古医科大学研究生学院
  • 张 翠英 内蒙古自治区人民医院肿瘤内科
关键词: CDK4/6;CDK4/6 抑制剂;联合用药;结直肠癌

摘要

细胞周期蛋白依赖性激酶 4/6(CDK4/6)抑制剂因有调控细胞周期、触发抗肿瘤免疫和改变肿瘤微环境等作用且在 抑制肿瘤细胞增殖、控制疾病进展和提高存活率方面显示出显著效果而备受青睐,已成为目前抗癌药物研发的热点。到目前 为止,已有 4 种高度选择性的 CDK4/6 抑制剂获批上市,分别是治疗乳腺癌的 Palbociclib、Ribociclib 和 Abemaciclib 以及治 疗小细胞肺癌的 Trilaciclib。大量研究发现,包括 CDK4/6 在内的多种 CDK 在结直肠癌(CRC)中异常表达,并可能参与 CRC 的发生、发展。且多项研究表明,细胞周期蛋白依赖性激酶抑制剂(CDKI)可增强化疗、靶向和免疫诱导的抗 CRC 作用, 从而提高了 CRC 的治愈率,可见 CDKI 与其他治疗的联合似乎为治愈 CRC 带来新的曙光。这篇综述中,我们将关注各种 CDK 的功能及其抑制剂(尤其是 CDK4/6 抑制剂)在 CRC 治疗中的潜在作用,旨在探讨 CDK4/6 抑制剂在 CRC 治疗中的应用前 景及优化手段。

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已出版
2023-07-27
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