甲磺酸奥西替尼治疗肺腺癌伴淀粉酶异常升高 1 例

  • 张 蕾 黑龙江省传染病防治院肿瘤科,中国·黑龙江 哈尔滨 150500
  • 王 春丽 黑龙江省传染病防治院肿瘤科,中国·黑龙江 哈尔滨 150500
  • 于 乐 黑龙江省传染病防治院肿瘤科,中国·黑龙江 哈尔滨 150500
关键词: 肺腺癌;淀粉酶;甲磺酸奥西替尼

摘要

肺腺癌伴淀粉酶升高患者临床上并不多见,甲磺酸奥西替尼是第三代酪氨酸激酶(EGFR-TKI)抑制剂,一线治疗伴有 EGFR突变阳性的非小细胞肺癌患者,本文探讨1 例48岁肺腺癌伴淀粉酶异常升高的男性患者,经过甲磺酸奥西替尼治疗后,肺部病灶明显好转,淀粉酶恢复正常;提示 EGFR-TKI 抑制剂对于肺腺癌伴高淀粉酶血症患者有明显疗效。

参考

Tsukawaki M, Izawa M, Yoshida M, Araki N, Hashiba Y, Nakagawa H, et

al. A case of amylase-producing lung cancer[J]. Intern Med. 1992;31:60-3.

Zhang J, Zhang l, Pan S, Gu B, Zhen Y, Yan J, Zhou Y. Amylase: sensitive

tumor marker for amylase-producing lung adenocarcinoma[J]. J Thorac Dis. 2013;

(4):167-9.

Yamazaki S, Ebisawa S, Yasuo M, Urushihata K, Koizumi T, Fujimoto K,

et al. Small-cell lung carcinoma produces salivary-type amylase: a case report with

review[J]. Intern Med. 2007; 46(12):883-7.

Weiss MJ, Edmondson HA, Wertman M. Elevated serum-amylase associated with bronchogenic carcinoma[J]. Am J Clin Pathol 1951; 21: 1057 1061.

Yuan YZ. New progress and new technique of Pancreatology[M].

Shanghai: ShangHai Scientific and Technological Literature Publishing House,

:283-285.

Yanagitani N, Kaira K, Sunaga N, et al. Serum amylase is a sensitive tumor

marker for amylase-producing small cell lung cancer?[J]. Int J Clin Oncol 2007;12:

-3.

Benedetti G, Rastelli F, Damiani S, et al. Challenging problems in

malignancy: case 1. Presentation of small-cell lung cancer with marked

hyperamylasemia[J]. J Clin Oncol 2004;22:3826-8.

Tohya T, Shimajiri S, Onoda C, et al. Complete remission of ovarian

endometrioid adenocarcinoma associated with hyperamylasemia and liver metastasis

treated by paclitaxel and carboplatin chemotherapy: a case report[J]. Int J Gynecol

Cancer 2004;14:378-80.

Kim SY, Kim JH, Kim CH, et al. A case of pheochromocytoma with

hyperamylasemia[J]. Korean J Gastroenterol 2003;42:172-5.

Jie Zhang, Lixia Zhang, Shiyang Pan, et al.Amylase: sensitive tumor marker

for amylase-producing lung adenocarcinoma[J].J Thorac Dis 2013;5(4):E167-E169.

Ko HW, Tsai YH, Yu CT, et al. Good response to gefitinib for lung

adenocarcinoma with hyperamylasemia: a case report[J]. Chang Gung Med J 2008;

:606-11.

已出版
2020-09-15
栏目
论文